Hot flashes may be welcome sign in women with breast cancer
Mortimer et al, 2007,
presented at the American Society of Clinical Oncology meeting, June 2007
 
Women on tamoxifen therapy who reported having hot flashes were less likely to develop recurrent breast cancer than those who did not report hot flashes, according to a study from the Moores Cancer Center at the University of California, San Diego ( UCSD ). Moreover, hot flashes were a stronger predictor of outcome than age, hormone receptor status or even how advanced the breast cancer was at diagnosis.
 
The study results were presented at the American Society for Clinical Oncology annual meeting in Chicago. “ Hot flashes are a very common and disruptive problem in breast cancer survivors ” said Dr Mortimer. “ About two-thirds of women with breast cancer say hot flashes compromised their quality of life. The most common request for additional treatment we get is for relief from these symptoms. ”
 
The study was based upon data from the comparison group of the Women’s Healthy Eating and Living ( WHEL ) study – a multi-site randomized trial of the impact of a diet high in vegetables, fruits and fibre, and low in fat on the recurrence of breast cancer. The WHEL participating institutions are University of California, San Diego and Davis, Stanford University, Kaiser Permanente in Oakland and Portland, University of Arizona, and the University of Texas M.D. Anderson Cancer Center in Houston.
 
Of the 1551 women with early stage breast cancer who were randomized to the comparison group of the WHEL study, more than half ( 864, or 56% ) were taking tamoxifen, and more than three-quarters of those ( 674 or 78% ) reported hot flashes.
 
Cancer recurrence among women who reported hot flashes was about 12%, compared with 21% for women not reporting hot flashes. These data were consistent across all years of follow-up, regardless of age or menopausal status.
 
“ This study provides the first evidence that hot flashes may be an indicator of a better prognosis in women with early stage breast cancer. ”
 
“ Our data support the possibility of a significant association between hot flashes and disease outcome. ”